The Prisma Health Office of Human Research Protection is responsible for reviewing all proposed research projects that involve Prisma Health patients or employees. The Prisma Health Institutional Review Board (IRB) is guided by applicable laws, regulations, and principles in its review and conduct of Human Subjects Research. The federal regulations governing human research grant the IRB an important charge to review and approve only research proposals that meet rigorous ethical and regulatory standards. The IRB provides ongoing oversight of approved research and is a key function of the Office of Human Research Protection. The Prisma Health IRB is comprised of three committees – Committee A, Committee C, and the Midlands Committee.